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Journal）》上。\n\n病原细菌是引发植物病害的重要元凶，传统检测方法依赖大型仪器和专业实验室，流程复杂且耗时，难以满足田间快速筛查需求。同时样品中细菌含量较低，加上杂质干扰，给精准检测带来挑战。\n\n科研团队设计出一种无需外接动力设备的“指压式”检测芯片，只需轻轻一按，液体便会在芯片内流动，依次完成样品反应和检测过程。芯片将不同反应过程分隔在独立空间中，有效减少相互干扰，检测结果更加稳定可靠。同时，搭建特殊纳米识别界面的芯片，能够像“生物雷达”一样精准锁定目标细菌，一旦目标出现，迅速启动信号放大过程，输出清晰可见的荧光结果，实现极低浓度细菌的快速读取。","中国农科院烟草所 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10:41·[世界农化网](https:\u002F\u002Fwww.toutiao.com\u002Fc\u002Fuser\u002Ftoken\u002FMS4wLjABAAAA-zO4FIkTaHs7RWfbEvMWSg5481TH8enpiYeOz5Z1r0U\u002F?source=tuwen_detail)\n\n**世界农化网中文网**报道：近日，中国农业科学院烟草研究所烟草病虫害绿色防控创新团队成功研发一种新型双金属人工水解酶，可高效降解细菌生物膜并杀死细菌，为细菌性病害绿色防控药剂的创制提供了全新设计策略。相关成果发表在国际顶级期刊《德国应用化学（Angewandte Chemie International Edition）》（IF=17.6），获选为当期封面文章，并被列为期刊热点论文（Hot Paper）。\n\n细菌生物膜是病原菌通过群体感应形成的胞外屏障，其结构完整性高度依赖于胞外多糖等大分子交织形成的骨架网络，可显著削弱防治药剂渗透与宿主免疫识别，是导致防治药剂防效骤降、田间病害反复暴发的核心诱因。\n\n针对制约农业细菌性病害防治的技术瓶颈，研究团队将高活性Ce4+引入金属有机框架，构建出具有双金属共定位活性中心的人工水解酶；通过密度泛函理论计算，首次阐明其区别于天然水解酶的独特催化路径。该酶具有良好的生物安全性和环境耐受性，可高效水解糖苷键，实现对细菌生物膜多糖骨架的靶向降解，生物膜清除率超80%，杀菌率超85%。\n\n![Image 1](https:\u002F\u002Fp3-sign.toutiaoimg.com\u002Ftos-cn-i-axegupay5k\u002Fcdccf90ebfd04a03bd2f35d88ecf8986~tplv-tt-origin-web:gif.jpeg?_iz=58558&from=article.pc_detail&lk3s=953192f4&x-expires=1786838058&x-signature=dKuFjAy4MNfETDD4afKqmWKTcqQ%3D)\n该成果突破传统杀菌剂依赖，首次将人工水解酶应用于生物膜的靶向清除，基于″解膜-杀菌″联动机制开辟了绿色防控新路径，对破解当前细菌性病害防治无特效药可用的产业困境具有重要现实意义。","中国农业科学院烟草所\u002F世界农化网 2026-08-06","2026-08-06T00:00:00Z",86,{"impact":79,"substance":80,"depth":17,"authority":81,"freshness":82,"relevant":22,"comment":83},25,22,13,8,"国家级科研机构重大突破，登顶刊封面，数据详实，对农业细菌病害防控有重要价值。",[85],{"name":75,"url":72},[27,58,28,87,88,89],"人工水解酶","细菌生物膜","Angewandte 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[针对无人机电子垃圾危机，天大团队《科学》发文](https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?type=detail&cat=T&id=572765&mobile=1)\n*   [“核聚山城?智驭靶向”：第十八届全国放射性药物与标记化合物学术交流会在重庆举办](https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?type=detail&cat=T&id=572754&mobile=1)\n*   [通往“器官再生之路”](https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?type=detail&cat=T&id=572753&mobile=1)\n*   [AI写的字，开始自带“暗号”](https:\u002F\u002Fwap.sciencenet.cn\u002Fmobile.php?type=detail&cat=T&id=572752&mobile=1)","中国科学报 科学网 2026-10-10","2026-10-10T00:00:00Z",73,{"impact":80,"substance":17,"depth":20,"authority":81,"freshness":67,"relevant":22,"comment":181},"报道中国农科院棉花高温逆境关键技术集成取得产量品质效益三丰收，属细分领域实质进展，但时效稍旧、信息增量有限，可入精选备选。",[183],{"name":177,"url":174},[185,27,186,187,188],"智慧农业","棉花","技术集成","高温逆境",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[],{"status":41,"locked":14,"version":42,"method":43,"evidence":192},{"candidates":193,"agricultural_evidence":48},[194,198],{"code":34,"score":125,"supported":48,"title":195,"abstract":196,"tags":197},[186],[186],[186],{"code":199,"score":22,"supported":14,"title":200,"abstract":201,"tags":202},"I1",[],[],[185],[204,205],"中国农科院 棉花 高温逆境","棉花 关键技术集成 产量品质","中国农科院棉花高温逆境-4766","2026-10-13T00:08:35.350655Z",{"id":209,"title":210,"url":211,"summary":212,"summary_zh":8,"content":213,"source_name":214,"source_url":8,"published_at":215,"category":12,"cover_url":8,"hotness":13,"is_selected":48,"score":216,"score_detail":217,"sources":219,"tags":221,"primary_topic":226,"secondary_topics":227,"classification":228,"search_phrases":250,"slug":253,"view_count":254,"doi":8,"paper":8,"created_at":255},944,"棉花专属知识大语言模型「棉芯1.0」发布 中国棉花产业迈入AI+科研+生产融合新阶段","https:\u002F\u002Fnews.gmw.cn\u002F2026-08\u002F26\u002Fcontent_38963850.htm","8月24日中国农业科学院棉花研究所联合西部农业研究中心发布全球首个棉花领域专属知识大语言模型「棉芯1.0」(CottonMind1.0)，采用「网页端+小程序端」双端设计：网页端为科研人员提供云端智研工作台(AI检索、文献加速阅读、知识图谱)，小程序端成为棉农随身「农技专家」(AI问答、拍照诊断、专家咨询)。模型已整合41680篇中外文科研文献、2000余项专利与国家标准、559部专业著作、1806条审定品种信息，覆盖基因功能、性状调控、品种选育、栽培管理、病虫害防控等全维度专业知识，并支持中英多语言服务。项目组负责人杨作仁表示，棉芯1.0打通了科研成果转化「最后一公里」，可服务于政府部门种植规划、防控策略与产业政策制定。","![Image 1](https:\u002F\u002Fimg.gmw.cn\u002Fpic\u002FgmwLogo_share.jpg)\n\n点击右上角![Image 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记者杨舒**从中国农业科学院棉花研究所获悉，24日，该所联合中国农业科学院西部农业研究中心正式发布全球首个棉花领域专属知识大语言模型——“棉芯1.0”（CottonMind1.0），标志着我国棉花产业迈入“AI+科研+生产”深度融合的新阶段。\n\n“棉芯1.0”以“网页端+小程序端”双端设计，分别瞄准科研创新与田间生产两大核心场景。网页端为科研人员提供云端智研工作台，集成AI智能检索、文献加速阅读、知识图谱可视化等功能。小程序端可以成为棉农的随身“农技专家”，提供AI问答、拍照诊断、专家在线咨询等服务，打破了传统农技服务的时空壁垒。此外，“棉芯1.0”全平台支持中文、英文等多语言服务，为国际棉花科研协作搭建了数字化桥梁。\n\n项目组负责人杨作仁介绍，“棉芯1.0”系统已整合全球41680篇中外文科研文献、2000余项专利与国家标准、559部专业著作、1806条审定品种信息，覆盖基因功能、性状调控、品种选育、栽培管理、病虫害防控等全维度专业知识。\n\n“棉芯1.0”的发布，是我国智慧农业建设在经济作物领域的重要突破。它打通了科研成果转化“最后一公里”，构建起“科研创新—技术推广—生产应用—数据反哺”的闭环生态。同时，“棉芯1.0”通过全产业数据归集与大数据分析，可为政府部门制定种植规划、防控策略与产业扶持政策提供科学数据支撑。\n\n《光明日报》（2026年08月26日 08版）\n\n[ 责编：赵靓 ]\n\n阅读剩余全文（）\n\n![Image 15](https:\u002F\u002Fimg.gmw.cn\u002Fcontent_banner\u002Fcontent_840x120_qrcodes.jpg)\n\n## 值班总编推荐\n\n*   [重视电动车治理是对道路交通安全负责](https:\u002F\u002Fguancha.gmw.cn\u002F2026-08\u002F25\u002Fcontent_38963649.htm)\n*   [高校选课季，如何让“金课”广受欢迎？](https:\u002F\u002Fnews.gmw.cn\u002F2026-08\u002F25\u002Fcontent_38961616.htm)\n*   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[光明网邮箱](https:\u002F\u002Fmail.gmw.cn\u002F)\n*   [网站地图](https:\u002F\u002Fwww.gmw.cn\u002Fmap.htm)\n\n![Image 20](https:\u002F\u002Fchannel-analysis.gmw.cn\u002F1.gif?s=1787702980444&cl=4108&pd=2026-08-26&ci=38963850&r=https:\u002F\u002Fnews.gmw.cn\u002F2026-08\u002F26\u002Fcontent_38963850.htm&at=%E8%B5%B5%E9%9D%93&tt=%E6%A3%89%E8%8A%B1%E4%B8%93%E5%B1%9E%E7%9F%A5%E8%AF%86%E5%A4%A7%E8%AF%AD%E8%A8%80%E6%A8%A1%E5%9E%8B%E2%80%9C%E6%A3%89%E8%8A%AF1.0%E2%80%9D%E5%8F%91%E5%B8%83%20_%E5%85%89%E6%98%8E%E7%BD%91)\n\n[](https:\u002F\u002Fwww.facebook.com\u002Fguangmingonline)[](https:\u002F\u002Fwww.facebook.com\u002Fguangmingonline)\n\n[](https:\u002F\u002Ftwitter.com\u002FGuangming_Daily)[](https:\u002F\u002Ftwitter.com\u002FGuangming_Daily)\n\n[](javascript:;)","光明日报 2026-08-26 第8版","2026-08-26T00:00:00Z",88,{"impact":79,"substance":80,"depth":19,"authority":124,"freshness":13,"relevant":22,"comment":218},"全球首个棉花专属大模型发布，标志产业迈入AI融合新阶段，信息详实，权威央媒报道，时效性强。",[220],{"name":214,"url":211},[185,27,222,223,224,225],"大语言模型","棉花所","棉芯1.0","经济作物",{"code":34,"slug":35,"name":36,"path":37,"parent_code":38},[],{"status":41,"locked":14,"version":42,"method":43,"evidence":229},{"candidates":230,"agricultural_evidence":48},[231,235,241,245],{"code":34,"score":47,"supported":48,"title":232,"abstract":233,"tags":234},[186],[186],[],{"code":236,"score":55,"supported":48,"title":237,"abstract":238,"tags":240},"G1",[],[239],"成果转化",[],{"code":199,"score":22,"supported":14,"title":242,"abstract":243,"tags":244},[],[],[185],{"code":246,"score":22,"supported":14,"title":247,"abstract":248,"tags":249},"I2",[],[],[222],[251,252],"中国农科院 大语言模型 智慧农业 经济作物","中国农科院 大语言模型","中国农科院大语言模型智慧农业经济作物-944",5,"2026-08-26T00:09:29.400381Z",{"id":257,"title":258,"url":259,"summary":260,"summary_zh":8,"content":261,"source_name":262,"source_url":8,"published_at":263,"category":12,"cover_url":8,"hotness":13,"is_selected":14,"score":264,"score_detail":265,"sources":267,"tags":269,"primary_topic":272,"secondary_topics":273,"classification":286,"search_phrases":327,"slug":330,"view_count":55,"doi":8,"paper":8,"created_at":331},435,"三节点采样方案实现滴灌棉田温室气体精准采集——中国农科院西部中心与棉花所建立干旱区棉田碳监测技术体系","https:\u002F\u002Fcaas.cn\u002Fxwzx\u002Fkyhd\u002F7ef7293fed924affbc040b406faa3a4e.htm","中国农业科学院西部农业研究中心联合棉花研究所揭示了干旱区滴灌棉田温室气体排放变化规律,建立了三节点滴灌棉田温室气体精准采集技术体系。膜下滴灌水肥一体化技术为新疆棉花高产稳产提供了重要技术支撑,但灌溉施肥过程会引起土壤温室气体排放快速波动,传统采样方式难以实现农田温室气体的精准监测。研究发现,灌溉施肥后第1天是温室气体排放峰值形成的关键时期,据此提出了'灌溉前1天—灌溉后1天—灌溉后5天'三节点精准采样方案,相关研究成果发表在《农业水管理》(Agricultural Water Management)上。","近日，中国农业科学院西部农业研究中心联合棉花研究所揭示了干旱区滴灌棉田温室气体排放变化规律，建立了三节点滴灌棉田温室气体精准采集技术体系。相关研究成果发表在《农业水管理（Agricultural Water Management）》上。\n\n膜下滴灌水肥一体化技术为新疆棉花高产稳产提供了重要技术支撑，但灌溉施肥过程会引起土壤温室气体排放快速波动，传统采样方式难以实现农田温室气体的精准监测。\n\n该研究发现，灌溉施肥后第1天是温室气体排放峰值形成的关键时期，据此提出了“灌溉前1天—灌溉后1天—灌溉后5天”三节点精准采样方案。该方案能够在减少采样工作量的同时，保留温室气体排放关键动态信息，保持较高的排放估算精度。研究构建的关键时期识别—精准采样优化—排放精准估算技术体系，为干旱区滴灌棉田温室气体监测提供了科学方案。","中国农业科学院 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