[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"topic-JIA":3},{"name":4,"kind":5,"tokens":6,"total":7,"page":8,"page_size":9,"items":10},"JIA","tag",[4],3,1,100,[11,61,98],{"id":12,"title":13,"url":14,"summary":15,"summary_zh":16,"content":17,"source_name":18,"source_url":16,"published_at":19,"category":20,"cover_url":16,"hotness":21,"is_selected":22,"score":23,"score_detail":24,"sources":30,"tags":32,"primary_topic":36,"secondary_topics":42,"classification":43,"search_phrases":55,"slug":58,"view_count":59,"doi":16,"paper":16,"created_at":60},563,"JIA 优先上线:江苏农科院刘永锋团队揭示稻曲病菌'劫持'海藻糖驱动稻曲球形成机制","https:\u002F\u002Fwap.sciencenet.cn\u002Fblog-3618084-1547738.html","江苏农科院植保所刘永锋团队在《Journal of Integrative Agriculture》发表论文,首次揭示稻曲病菌通过两个功能分化的海藻糖酶基因 UvNTH 与 UvATH 实现精准分工,其中 UvNTH 是稻曲球形成的特异性毒力开关。敲除 UvNTH 后病菌虽能定殖但完全丧失形成稻曲球的能力,首次将'侵染定殖'与'成球症状'解耦。",null,"Journal of Integrative AgricultureũҵѧѧӢģ, JIAл񹲺͹ũҵũ岿ܣйũҵѧԺйũѧ죬йũҵѧԺũҵϢоа졣ۺӢѧڿ¿2002꣬ΪйѧԺԺʿ»JIAҪĿѧ԰աֲﱣѧҽѧũҵ̬ʳƷѧũҵȡоġԼȡȫElsevier-ScienceDirect (SD) ƽ̨OA档SCIӰ5.7λSCI-JCRũҵۺѧQ1йѧԺũֿѧ12016ȺйЭȲί ƻǷƻ׿ԽƻĿ֧֡","科学网博客 2026-08-13 江苏省农业科学院","2026-08-13T00:00:00Z","报道",10,false,64,{"impact":25,"substance":26,"depth":27,"authority":21,"freshness":28,"relevant":8,"comment":29},20,15,12,7,"报道了江苏农科院在稻曲病研究上的新进展，属于农业科技领域，但信息较为简略，缺乏具体数据，权威性中等。",[31],{"name":18,"url":14},[33,4,34,35],"江苏省农科院","稻曲病","海藻糖",{"code":37,"slug":38,"name":39,"path":40,"parent_code":41},"F4","crop-protection","农药与绿色防控","\u002Ftopic\u002Finputs-equipment\u002Fcrop-protection","F",[],{"status":44,"locked":22,"version":45,"method":46,"evidence":47},"classified","2026-10-22.2","rules",{"candidates":48,"agricultural_evidence":50},[49],{"code":37,"score":7,"supported":50,"title":51,"abstract":52,"tags":54},true,[],[53],"植保",[],[56,57],"江苏省农科院 海藻糖 稻曲病 JIA","江苏省农科院 海藻糖","江苏省农科院海藻糖稻曲病JIA-563",2,"2026-08-15T23:54:32.247170Z",{"id":62,"title":63,"url":64,"summary":65,"summary_zh":16,"content":66,"source_name":67,"source_url":16,"published_at":68,"category":20,"cover_url":16,"hotness":21,"is_selected":22,"score":69,"score_detail":70,"sources":73,"tags":75,"primary_topic":79,"secondary_topics":84,"classification":85,"search_phrases":93,"slug":96,"view_count":7,"doi":16,"paper":16,"created_at":97},561,"JIA 8 期:长期石灰改良通过调控铁铝氧化物促进红壤有机碳固存","https:\u002F\u002Fbbs.sciencenet.cn\u002Fblog-3618084-1548057.html","资划所张会民团队基于湖南祁阳 1990 年起的红壤施肥定位试验研究表明,与单施化肥相比,化肥配施石灰(NCa)使 0-10、10-20 cm 土层 SOC 分别提高 20.8% 和 15.2%,显著提高 0-10 cm 土层 SOC 储量和碳固存效率。研究为酸性红壤区碳固存提供了施肥-石灰协同调控的科学依据。","Journal of Integrative Agriculture (ũҵѧѧ(Ӣ), JIA) л񹲺͹ũҵũ岿ܣйũҵѧԺйũѧ죬йũҵѧԺũҵϢоа졣ۺӢѧڿ¿2002꣬ΪйѧԺԺʿ»JIAҪĿѧ԰աֲﱣѧҽѧũҵ̬ʳƷѧũҵȡоġԼȡȫElsevier-ScienceDirect (SD) ƽ̨OA档SCIӰ5.7λSCI-JCRũҵۺѧQ1йѧԺũֿѧ12016ȺйЭȲί ƻǷƻ׿ԽƻĿ֧","科学网博客 2026-08-14 中国农业科学院农业资源与农业区划研究所","2026-08-14T00:00:00Z",63,{"impact":26,"substance":26,"depth":27,"authority":27,"freshness":71,"relevant":8,"comment":72},9,"报道了红壤有机碳固存研究进展，属于农业科技领域，但内容较简略，影响范围有限。",[74],{"name":67,"url":64},[76,4,77,78],"中国农科院","红壤改良","有机碳",{"code":80,"slug":81,"name":82,"path":83,"parent_code":41},"F3","fertilizers","肥料与水肥一体化","\u002Ftopic\u002Finputs-equipment\u002Ffertilizers",[],{"status":44,"locked":22,"version":45,"method":46,"evidence":86},{"candidates":87,"agricultural_evidence":50},[88],{"code":80,"score":7,"supported":50,"title":89,"abstract":90,"tags":92},[],[91],"施肥",[],[94,95],"中国农科院 红壤改良 有机碳 JIA","中国农科院 红壤改良","中国农科院红壤改良有机碳JIA-561","2026-08-15T23:54:32.209344Z",{"id":99,"title":100,"url":101,"summary":102,"summary_zh":16,"content":103,"source_name":104,"source_url":16,"published_at":19,"category":20,"cover_url":16,"hotness":21,"is_selected":22,"score":105,"score_detail":106,"sources":112,"tags":114,"primary_topic":117,"secondary_topics":123,"classification":124,"search_phrases":132,"slug":135,"view_count":8,"doi":16,"paper":16,"created_at":136},560,"JIA 优先上线:中国农科院哈兽研基础免疫团队揭示 ASFV pA151R 抑制应激颗粒形成的关键机制","https:\u002F\u002Fbbs.sciencenet.cn\u002Fblog-3618084-1547906.html","哈兽研翁长江、黄丽团队在《Journal of Integrative Agriculture》在线发表论文,揭示非洲猪瘟病毒 pA151R 通过抑制 NXT1 启动子活性阻断 mRNA 核输出,进而抑制应激颗粒(SGs)形成与宿主蛋白合成的分子机制。A151R 基因缺失重组病毒复制能力降低,对 SGs 形成和天然免疫的抑制作用减弱,为开发抗 ASFV 药物和疫苗提供潜在靶点。","非洲猪瘟（ASF）是由非洲猪瘟病毒（ASFV）引起的一种高度致死性动物疫病，严重威胁全球养猪产业健康发展。应激颗粒（SGs）是应激诱导哺乳动物细胞形成的一种无膜聚集体，通过隔离病毒组分并调控抗病毒信号通路来抑制病毒复制。此前研究报道ASFV感染抑制SGs的形成，但参与调控SGs形成的病毒蛋白及其潜在分子机制仍不清楚。\n\n近期，中国农业科学院哈尔滨兽医研究所 翁长江研究员 和 黄丽研究员 团队 完成的题为“**African swine fever virus pA151R inhibits stress granule formation and host protein synthesis by disrupting mRNA nuclear export**”的研究 在**_Journal of Integrative A_****_gricultur_****_e（《农业科学学报_（英文）》，JIA）**优先在线发表。\n\n**本研究揭示了ASFV pA151R通过抑制NXT1启动子活性阻断mRNA核输出，进而抑制SGs形成与宿主蛋白合成的分子机制。A151R基因缺失显著减弱ASFV对SGs形成与宿主天然免疫的抑制作用，为阐明ASFV免疫逃逸机制及开发抗病毒药物提供了重要依据。**\n\n主要发现：\n\n**锁定新靶标：****ASFV pA151R抑制SGs形成**\n\n研究团队通过筛选鉴定发现，ASFV pA151R显著抑制eIF2α依赖与非依赖途径诱导的SGs形成。通过cNLS mapper预测，研究团队发现pA151R存在一个核定位信号（NLS）。删除该NLS显著减弱pA151R对SGs形成的抑制作用。\n\n![Image 1: 11.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140421fnrattn33z55fwbt.png)\n\n图1 ASFV pA151R抑制SGs形成依赖其NLS基序\n\n**揭示新机制：****ASFV pA151R调控mRNA核质运输**\n\n由于SGs形成依赖胞质中的mRNA形成核心骨架，因此研究团队通过原位杂交实验发现，pA151R能够导致poly(A)+ mRNA滞留于细胞核。进一步研究表明，pA151R通过抑制NXT1启动子活性下调其表达，进而阻碍mRNA出核，抑制SGs的形成与宿主蛋白合成。\n\n![Image 2: 12.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140426u9ciklizrzwh44xa.png)\n\n图2 ASFV pA151R抑制mRNA核质运输\n\n**验证复制相关基因功能：****A151R是ASFV的复制相关基因****与免疫抑制基因**\n\n为在病毒水平验证pA151R的生物学功能，研究团队基于ASFV Pig\u002FHLJ\u002F18毒株成功构建了A151R基因缺失重组病毒（ASFV-ΔA151R）。与野生型病毒相比，ASFV-ΔA151R的复制能力降低，并且对SGs形成与天然免疫的抑制作用减弱。\n\n![Image 3: 13.png](http:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202608\u002F14\u002F140431kjggi5vj8g9jystv.png)\n\n图3 ASFV-△A151R的复制能力较低，对SGs形成的抑制作用减弱\n\n本研究发现ASFV pA151R是抑制SGs形成与宿主蛋白合成的关键因子，并阐明了pA151R通过限制mRNA核质运输和调节宿主蛋白合成抑制SGs形成，从而为病毒复制和免疫逃避创造有利环境的分子基础。研究结果不仅揭示了A151R作为复制相关基因在病毒免疫逃逸过程中的新功能，而且为开发抗ASFV药物和疫苗提供了潜在的靶点。\n\n中国农业科学院哈尔滨兽医研究所 博士研究生董思琦 为论文第一作者，翁长江研究员 与 黄丽研究员 为共同通讯作者。本研究得到了国家自然科学基金（32322081）等项目的资助。\n\nCite the article:Siqi Dong, Tingting Li, Longfei Han, Xiaoping He, Xiaohong Liu, Hanyu Wu, Changjiang Weng, Li Huang. 2026. African swine fever virus pA151R inhibits stress granule formation and host protein synthesis by disrupting mRNA nuclear export. Journal of Integrative Agriculture, Doi:10.1016\u002Fj.jia.2026.06.008\n\n[https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jia.2026.06.008](https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.jia.2026.06.008)\n\n_Journal of Integrative Agriculture_（《农 业科学学报（英文）》, JIA）由中华人民共和国农业农村部主管，中国农业科学院与中国农学会主办，中国农业科学院农业信息研究所承办。综合性英文学术期刊，月刊。创刊于2002年，现任主编为中国科学院院士陈化兰。JIA主要栏目有作物科学、园艺、植物保护、动物科学、动物医学、农业生态环境、食品科学、农业经济与管理等。刊稿类型有综述、研究论文、简报以及评述等。全部论文在Elsevier-ScienceDirect (SD) 平台OA出版。最新SCI影响因子5.7，位于SCI-JCR农业综合学科Q1区。中国科学院分区农林科学1区。2016年以来先后获得中国科协等部委 “提升计划”“登峰计划”“卓越计划”项目支持。\n\n转载本文请联系原作者获取授权，同时请注明本文来自王宁科学网博客。\n\n链接地址： [https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547906.html](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547906.html)\n\n上一篇：[JIA封面文章 | 扬州大学兽医学院李向东教授团队系统揭示全球类NADC34猪繁殖与呼吸综合征病毒的重组演化动态](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547887.html)\n\n下一篇：[JIA｜中国农业大学水稻研究中心朱作峰团队揭示了非洲栽培稻进化过程中护颖变长的遗传控制](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-3618084-1547959.html)\n\n[欢迎参加科学网十佳博文评选活动！](https:\u002F\u002Fblog.sciencenet.cn\u002Fblog-45-1520553.html)\n\n主办单位： [![Image 4](https:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202606\u002F03\u002F170346g6h6jzlddzxnvgk1.jpg)](https:\u002F\u002Fwww.sciencenet.cn\u002F)支持单位：[![Image 5](https:\u002F\u002Fimage.sciencenet.cn\u002Fhome\u002F202606\u002F04\u002F150033i1jb7dpbv12pbsbs.jpg)](https:\u002F\u002Fais.cn\u002Fu\u002FQnia6z)","科学网博客 2026-08-13 中国农业科学院哈尔滨兽医研究所",84,{"impact":107,"substance":107,"depth":108,"authority":109,"freshness":110,"relevant":8,"comment":111},22,18,14,8,"揭示ASFV免疫逃逸新机制，对非洲猪瘟防控有重要科学价值，但属细分领域进展，影响范围有限。",[113],{"name":104,"url":101},[76,115,116,4],"非洲猪瘟","应激颗粒",{"code":118,"slug":119,"name":120,"path":121,"parent_code":122},"C5","animal-health","疫病防控与兽药","\u002Ftopic\u002Flivestock\u002Fanimal-health","C",[],{"status":44,"locked":22,"version":45,"method":46,"evidence":125},{"candidates":126,"agricultural_evidence":50},[127],{"code":118,"score":128,"supported":50,"title":129,"abstract":130,"tags":131},4,[],[115],[115],[133,134],"中国农科院 应激颗粒 非洲猪瘟 JIA","中国农科院 应激颗粒","中国农科院应激颗粒非洲猪瘟JIA-560","2026-08-15T23:54:32.189393Z"]