[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"item-3484":3,"related-3484":50},{"id":4,"title":5,"url":6,"summary":7,"summary_zh":8,"content":9,"source_name":10,"source_url":6,"published_at":11,"category":12,"cover_url":9,"hotness":13,"is_selected":14,"score":15,"score_detail":16,"sources":18,"tags":20,"search_phrases":24,"slug":27,"view_count":15,"doi":28,"paper":29,"created_at":49},3484,"Failure to classically condition G. dorotocephala and S. mediterranea flatworms using historical and contemporary light-shock paradigms","https:\u002F\u002Fdoi.org\u002F10.1371\u002Fjournal.pone.0358756","Planarian flatworms represent one of the most evolutionarily informative nervous systems for an account of ancient bilaterian brains. Likewise, the unparalleled regenerative ability of planarians makes possible certain investigations of neural development, memory, and behavior that are simply impossible with other model organisms. Despite these facts, learning and memory are today underexplored in planarians, likely due in part to the controversial legacy of 20th-century experiments on the transfer of memories between individual flatworms. Here, we attempted to replicate and extend the classical conditioning experiments in planarians that were the basis of the later memory transfer work. We failed to find evidence of learning using both historical and contemporary conditioning protocols, and using computer vision methods to avoid subjectivity in manual video annotation. Our results cast doubt on the suitability of historic conditioning protocols for Girardia dorotocephala and Schmidtea mediterranea planarians. We encourage future researchers to explore more ethologically relevant conditioning paradigms to establish a behavioral foundation for investigating the molecular basis of learning.","涡虫扁虫（planarian flatworms）为理解古代两侧对称动物大脑提供了最具演化信息价值的神经系统之一。同样，涡虫无与伦比的再生能力使得某些关于神经发育、记忆和行为的探究成为可能，而这些研究在其他模式生物上根本无法进行。尽管如此，涡虫的学习与记忆研究如今仍未被充分探索，部分原因可能在于20世纪关于个体扁虫间记忆转移实验颇具争议的历史遗产。在此，我们尝试重复并拓展涡虫中的经典条件反射实验——这些实验正是后来记忆转移工作的基础。我们采用历史性和当代的条件反射方案，并运用计算机视觉方法以避免人工视频标注中的主观性，但未能发现学习的证据。我们的结果对历史性条件反射方案适用于Girardia dorotocephala和Schmidtea mediterranea涡虫的适宜性提出了质疑。我们鼓励未来的研究者探索更具行为学相关性的条件反射范式，为研究学习的分子基础建立行为学基础。",null,"PLoS ONE","2026-09-23T00:00:00Z","论文",10,false,0,{"impact":15,"substance":15,"depth":15,"authority":15,"freshness":15,"relevant":15,"comment":17},"该研究属基础神经生物学范畴，与三农、农业信息化、智慧农业等主题无关，不建议进入每日精选。",[19],{"name":10,"url":6},[21,22,23],"动物行为学","学习记忆","涡虫再生",[25,26],"涡虫 经典条件反射","动物行为学 学习记忆 涡虫再生","涡虫经典条件反射-3484","10.1371\u002Fjournal.pone.0358756",{"doi":28,"openalex_id":30,"authors":31,"venue":10,"cited_by_count":15,"oa_url":40,"card":41,"direction":47,"ingested_from":48},"W7214119139",[32,35,37],{"name":33,"orcid":34},"Zachary S Kelso","https:\u002F\u002Forcid.org\u002F0009-0009-8817-3099",{"name":36,"orcid":9},"Madeleine C. Snyder",{"name":38,"orcid":39},"Samuel J. Gershman","https:\u002F\u002Forcid.org\u002F0000-0002-6546-3298","https:\u002F\u002Fjournals.plos.org\u002Fplosone\u002Farticle\u002Ffile?id=10.1371\u002Fjournal.pone.0358756&type=printable",{"tldr":42,"method":43,"finding":44,"direction":45,"opportunity":46},"尝试复现涡虫经典条件反射实验，用历史与当代范式均未发现学习证据。","对两种涡虫采用光-电击条件反射范式，并用计算机视觉分析视频。","两种涡虫在历史与当代条件反射方案下均未表现出学习，质疑旧方案适用性。","其他","可探索更符合生态习性的条件反射范式，为涡虫学习记忆分子机制研究奠定行为基础。","农业遥感与作物表型","openalex","2026-09-25T23:30:21.616054Z",{"total":15,"page":51,"page_size":51,"items":52},1,[]]