[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"item-3566":3,"related-3566":52},{"id":4,"title":5,"url":6,"summary":7,"summary_zh":8,"content":9,"source_name":10,"source_url":6,"published_at":11,"category":12,"cover_url":9,"hotness":13,"is_selected":14,"score":15,"score_detail":16,"sources":18,"tags":20,"search_phrases":25,"slug":28,"view_count":15,"doi":29,"paper":30,"created_at":51},3566,"Protective Effects of Viburnum opulus L. (Gilaburu) on Amiodarone-Induced Hepatorenal Toxicity in Rats","https:\u002F\u002Fdoi.org\u002F10.17343\u002Fsdutfd.1909295","ObjectiveAmiodarone is a widely prescribed antiarrhythmicagent, yet hepatotoxic and nephrotoxic side effectsfrequently limit its clinical use. Viburnum opulus L. (Gilaburu),a fruit native to the Kayseri region of Türkiye,is notable for its antioxidative, antiproliferative, andanti-inflammatory properties. Its rich composition oforganic acids, phenolic compounds, amino acids, andvitamins suggests potential protective effects againstdrug-induced organ injury.Material and MethodThis study investigated the structural and biochemicalchanges induced by amiodarone in rat liver andkidney tissues, as well as the potential protective effectsof gilaburu. Thirty-two male Wistar rats (300–350g) were randomly assigned to four groups: control,amiodarone, amiodarone plus gilaburu, and gilaburu.Amiodarone was administered intraperitoneally at 100mg\u002Fkg\u002Fday for 10 days, while gilaburu fruit extract wasgiven orally at 100 mg\u002Fkg\u002Fday. At the end of treatment,hepatic and renal tissues were analyzed histochemicallyand immunohistochemically, and serum biochemicalparameters were assessed.ResultsHistological evaluation revealed pronounced hepaticand renal damage in the amiodarone group, which wasmarkedly reduced in the combined treatment group.Immunohistochemical staining for tumor necrosis factor-alpha and inducible nitric oxide synthase showedsignificantly higher expression in the amiodaronegroup compared with the combined group (p \u003C 0.05).Biochemical analyses, including total antioxidant status,total oxidant status, and oxidative stress index,supported these findings.ConclusionGilaburu fruit extract demonstrated significant protectiveeffects against amiodarone-induced hepatic andrenal injury. These results highlight its potential as anatural antioxidant agent that may mitigate drug-inducedorgan toxicity.","目的：胺碘酮（Amiodarone）是一种广泛使用的抗心律失常药物，但其肝毒性和肾毒性副作用常常限制其临床应用。荚蒾（Viburnum opulus L.，Gilaburu）是土耳其开塞利地区原产的一种果实，以其抗氧化、抗增殖和抗炎特性而著称。其富含有机酸、酚类化合物、氨基酸和维生素，提示其可能对药物诱导的器官损伤具有保护作用。\n\n材料与方法：本研究探讨了胺碘酮对大鼠肝脏和肾脏组织引起的结构和生化改变，以及荚蒾可能的保护作用。将32只雄性Wistar大鼠（300–350g）随机分为四组：对照组、胺碘酮组、胺碘酮加荚蒾组和荚蒾组。胺碘酮以100 mg\u002Fkg\u002F天的剂量腹腔注射，连续10天；荚蒾果实提取物以100 mg\u002Fkg\u002F天的剂量口服给药。治疗结束后，对肝脏和肾脏组织进行组织化学和免疫组织化学分析，并评估血清生化指标。\n\n结果：组织学评估显示，胺碘酮组出现明显的肝脏和肾脏损伤，而联合治疗组的损伤显著减轻。肿瘤坏死因子-α和诱导型一氧化氮合酶的免疫组织化学染色显示，胺碘酮组的表达显著高于联合治疗组（p \u003C 0.05）。生化分析，包括总抗氧化状态、总氧化状态和氧化应激指数，均支持上述发现。\n\n结论：荚蒾果实提取物对胺碘酮诱导的肝脏和肾脏损伤表现出显著的保护作用。这些结果凸显了其作为一种天然抗氧化剂的潜力，可能有助于减轻药物诱导的器官毒性。",null,"SDÜ Tıp Fakültesi Dergisi","2026-09-24T00:00:00Z","论文",10,false,0,{"impact":15,"substance":15,"depth":15,"authority":15,"freshness":15,"relevant":15,"comment":17},"该文为药理毒理学动物实验研究，与三农、农业信息化、智慧农业等主题无关，不建议进入每日精选。",[19],{"name":10,"url":6},[21,22,23,24],"抗氧化","药用植物","肝肾保护","大鼠实验",[26,27],"Viburnum opulus 荚蒾","amiodarone 肝肾毒性","Viburnumopulus荚蒾-3566","10.17343\u002Fsdutfd.1909295",{"doi":29,"openalex_id":31,"authors":32,"venue":10,"cited_by_count":15,"oa_url":42,"card":43,"direction":49,"ingested_from":50},"W7214210288",[33,36,39],{"name":34,"orcid":35},"Dilek Bayram","https:\u002F\u002Forcid.org\u002F0000-0003-3568-2673",{"name":37,"orcid":38},"Nazife Karakeçi","https:\u002F\u002Forcid.org\u002F0000-0001-8119-078X",{"name":40,"orcid":41},"Şükriye Yeşilot","https:\u002F\u002Forcid.org\u002F0000-0003-3354-8489","https:\u002F\u002Fdergipark.org.tr\u002Fen\u002Fdownload\u002Farticle-file\u002F5812950",{"tldr":44,"method":45,"finding":46,"direction":47,"opportunity":48},"研究荚蒾果提取物对胺碘酮致大鼠肝肾毒性的保护作用。","32只大鼠分4组，胺碘酮与荚蒾果提取物干预，组织化学与生化检测。","荚蒾果提取物显著减轻胺碘酮引起的肝肾损伤与氧化应激。","其他","可探索天然植物提取物作为药物性器官损伤保护剂的机制与转化。","农业人工智能与决策模型","openalex","2026-09-26T23:30:50.354505Z",{"total":53,"page":53,"page_size":53,"items":54},1,[55],{"id":56,"title":57,"url":58,"summary":59,"summary_zh":60,"content":9,"source_name":61,"source_url":58,"published_at":62,"category":12,"cover_url":9,"hotness":13,"is_selected":14,"score":63,"score_detail":64,"sources":71,"tags":73,"search_phrases":78,"slug":81,"view_count":53,"doi":82,"paper":83,"created_at":126},2031,"Influence of edaphic conditions on the biochemical composition and antioxidant and antimicrobial activities of Ceratonia siliqua L. pulp in the Moroccan Middle Atlas","https:\u002F\u002Fdoi.org\u002F10.3389\u002Ffsufs.2026.1885486","The carob tree ( Ceratonia siliqua L. ), a leguminous species, is a tree of significant socio-economic, environmental, industrial, and pharmacological value within agro-sylvo-pastoral systems. The carob pulp is utilized despite its antioxidant activity and its richness in bioactive compounds. This study highlights the influence of edaphic conditions on the biochemical compounds in and antioxidant and antimicrobial activities of the Ceratonia siliqua L. pulp in six geographic zones in the Middle Atlas of Morocco. Carob pulp extract (PE) from Sidi Hsine had the highest level of bioactive compounds: 2.36 ± 0.03 mg GA eq\u002Fg dry weight and 2.007 ± 0.017 mg rutin eq\u002Fg DM for total polyphenols and flavonoids, respectively, with heavy-metal rich soil. The carob PE from Lehri had the highest content of water-soluble tannins (6.846 ± 0.061 mg EAT\u002Fg DM) and the lowest calcium and highest iron level in the soil. Principal Component Analysis revealed the effect of soil analysis on carob biochemical composition, bioactive compounds, and antioxidant and antimicrobial activities. This work provides insight into the carob pulp from each zone and its value based on its biochemical composition, bioactive compounds, and antioxidant and antimicrobial activities.","角豆树（Ceratonia siliqua L.）是一种豆科树种，在农林牧系统中具有重要的社会经济、环境、工业和药理价值。尽管角豆果肉具有抗氧化活性且富含生物活性化合物，但其利用仍不充分。本研究揭示了摩洛哥中阿特拉斯山脉六个地理区域内土壤条件对角豆果肉生化化合物、抗氧化及抗菌活性的影响。来自Sidi Hsine的角豆果肉提取物（PE）具有最高水平的生物活性化合物：总多酚和总黄酮分别为2.36 ± 0.03 mg GA当量\u002Fg干重和2.007 ± 0.017 mg芦丁当量\u002Fg干重，其土壤富含重金属。来自Lehri的角豆PE具有最高的水溶性单宁含量（6.846 ± 0.061 mg EAT\u002Fg干重），其土壤钙含量最低、铁含量最高。主成分分析揭示了土壤分析结果对角豆生化组成、生物活性化合物以及抗氧化和抗菌活性的影响。本研究为了解各区域的角豆果肉及其基于生化组成、生物活性化合物和抗氧化及抗菌活性的价值提供了见解。","Frontiers in Sustainable Food Systems","2026-09-09T00:00:00Z",64,{"impact":65,"substance":66,"depth":67,"authority":68,"freshness":69,"relevant":53,"comment":70},8,18,16,13,9,"摩洛哥角豆树浆的土壤-品质关系研究，方法规范、数据具体，但属区域性基础研究，对国内农业信息化与产业实践参考价值有限。",[72],{"name":61,"url":58},[74,75,76,21,77],"角豆树","土壤条件","生物活性成分","经济林",[79,80],"生物活性成分 土壤条件 抗氧化 经济林","生物活性成分 土壤条件","生物活性成分土壤条件抗氧化经济林-2031","10.3389\u002Ffsufs.2026.1885486",{"doi":82,"openalex_id":84,"authors":85,"venue":61,"cited_by_count":15,"oa_url":58,"card":120,"direction":124,"ingested_from":50},"W7212054225",[86,89,91,93,96,99,102,105,108,110,112,114,117],{"name":87,"orcid":88},"Fatima-Ezzahra Eddabbeh","https:\u002F\u002Forcid.org\u002F0000-0002-0454-1870",{"name":90,"orcid":9},"Abdelaaty A. Shahat",{"name":92,"orcid":9},"Sabir Ouahhoud",{"name":94,"orcid":95},"Sara Moumnassi","https:\u002F\u002Forcid.org\u002F0009-0009-7363-2571",{"name":97,"orcid":98},"Ayoub Ainane","https:\u002F\u002Forcid.org\u002F0000-0002-5004-6416",{"name":100,"orcid":101},"Salma Kadda","https:\u002F\u002Forcid.org\u002F0000-0003-4348-743X",{"name":103,"orcid":104},"Joe Miantezila Basilua","https:\u002F\u002Forcid.org\u002F0000-0002-5658-9382",{"name":106,"orcid":107},"Rashed N. Herqash","https:\u002F\u002Forcid.org\u002F0000-0002-4502-9507",{"name":109,"orcid":9},"Bouchra El Guerrouj",{"name":111,"orcid":9},"Ennouamane Saalaoui",{"name":113,"orcid":9},"Abdeslam Asehraou",{"name":115,"orcid":116},"Fatouma Mohamed Abdoul‐Latif","https:\u002F\u002Forcid.org\u002F0000-0001-7213-4700",{"name":118,"orcid":119},"Tarik Ainane","https:\u002F\u002Forcid.org\u002F0000-0001-6743-2666",{"tldr":121,"method":122,"finding":123,"direction":124,"opportunity":125},"研究摩洛哥中阿特拉斯六个地区土壤条件对角豆果肉生化成分及抗氧化抗菌活性的影响。","采集六区角豆果肉与土壤，测定多酚、黄酮、单宁及抗氧化抗菌活性，用主成分分析关联土","土壤重金属、钙铁等显著影响果肉活性成分，Sidi Hsine多酚黄酮最高，Lehri水溶性单宁最高。","农业绿色发展与碳","可探究土壤-作物活性成分关联机制，建立基于土壤调控的功能性农产品定向栽培与品质预测模型。","2026-09-10T23:30:07.516002Z"]