Genetic hitchhikers make Aspergillus infections even harder to treat
Resistance to antifungal medicines in the pathogenic fungus Aspergillus fumigatus is proving more persistent than previously thought. Research by Wageningen University & Research (WUR), published in Current Biology, shows that fungicides used in agriculture, even those with a different mode of action from these medicines, can help maintain this resistance. This is because different resistance genes "hitchhike" together.
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该研究首次通过自家庭院割草实验证明,非唑类农业杀菌剂也能维持曲霉对医用唑类的抗性,提示仅禁用农业唑类不足以遏制耐药,需将多类杀菌剂纳入抗性管理考量。
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